“Supercharged” vitamin K derivatives offer new hope for neurodegenerative diseases
Researchers synthesized a series of hybrid vitamin?K analogues (linked with retinoic acid or modified side chains) that show about threefold greater potency in driving neural progenitor cells to differentiate into neurons compared to natural vitamin?K (MK?4). Mechanistic studies revealed that vitamin?K activates mGluR1?mediated signaling, triggering…
